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KMID : 0363220110490070565
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Korean Journal of Dermatology
2011 Volume.49 No. 7 p.565 ~ p.571
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Efficacy of Tranexamic Acid Containing Oral Medication on Melasma
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Shin Jung-Won
Huh Sun-Young
Jeong Jeong-Bok
Park Kyoung-Chan
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Abstract
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Background: Melasma causes considerable cosmetic disfigurement and none of the existing treatment modalities are satisfactory. Recently tranexamic acid has been reported to reduce hyperpigmentation in patients with melasma.
Objective:The purpose of the study was to evaluate the efficacy and safety of tranexamic acid containing oral
medication for the treatment of melasma.
Methods: Forty-five female volunteers who had been diagnosed with melasma were enrolled in the present study. Patients were instructed to take medication for 8 weeks. The melanin index (MI) and erythema index (EI) were
measured at baseline, and at 4 and 8 weeks. The melasma area and severity index (MASI) was scored at 0, 4, and
8 weeks. Self-satisfaction and safety evaluations were also performed at each visit.
Results: The mean MI measured on the lesional skin was decreased at 4 and 8 weeks compared with baseline (p＜0.01 for both). The mean EI measured on the lesional skin and the MASI also showed a significant decrease from
baseline to 8 weeks (p＜0.001 for EI and p=0.020 for MASI). Based on self-assessment, 39.5% of the patients were
very satisfied, 44.2% were satisfied, and 11.6% felt moderate improvement after 8 weeks of medication; only 2
patients (4.7%) were dissatisfied. Thus, ＞80% of patients were satisfied with the medication. Adverse effects were
minimal and two patients dropped out of the study due to drug-related urticaria and unexpected pregnancy.
Conclusion: Tranexamic acid-containing oral medication is an effective and safe therapeutic modality for the
treatment of melasma.
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KEYWORD
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Erythema index, EI, Melanin index, MI, Melasma, Tranexamic acid
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